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In vitro demonstration of melanoma metastasis in lymph nodes of prepared specimens using a light-emitting diode-based multispectral photoacoustic ultrasound imaging system


1 Department of Radiology, International University of Health and Welfare Hospital, Otawara, Tochigi, Japan
2 Department of Radiological Science, Tokyo Metropolitan University Graduate School of Health Science, Tokyo, Japan
3 Department of Pathology, International University of Health and Welfare Hospital, Otawara, Tochigi, Japan
4 Department of Plastic Surgery, International University of Health and Welfare Hospital, Otawara, Tochigi, Japan

Correspondence Address:
Tomoyuki Ohta,
Department of Radiology, International University of Health and Welfare Hospital, Iguchi 537-3, Nasushiobara City, Tochigi 329-2763
Japan
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Source of Support: None, Conflict of Interest: None

Although an excellent photoacoustic (PA) ultrasound method has been reported for the evaluation of lymph node melanoma metastasis in animal experiments, it remains to be evaluated in clinical trials. Recently, we performed PA ultrasound assessment using light-emitting diodes to detect metastatic melanoma in the lymph nodes of specimens prepared for microscopic examination. The PA effect was not obvious in amelanotic melanoma, but was seen in melanotic melanoma by PA imaging (PAI) and histopathological correlation in cases of primary melanotic melanoma accompanied by metastatic lymph nodes, including the coexistence of amelanotic melanoma and melanotic melanoma. Clinical workup should be performed with not only PAI but also conventional ultrasonography in cases with metastasis related to amelanotic transformation, which would likely be missed by PAI alone.


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    -  Ohta T
    -  Shirakawa T
    -  Okada S
    -  Ishii N
    -  Kiryu S
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